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Hence, the metabolite is chargeable for about 20% of sildenafil's motion. Sildenafil is excreted as metabolites predominantly from the feces (about eighty% of administered oral dose) and to a lesser extent during the urine (all-around 13% with the administered oral dose). If taken having a large-fat meal, absorption is minimized; the time taken to succeed in the maximum plasma concentration boosts by all around one hour, and the utmost concentration itself is diminished by approximately a single-third.[52]
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